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Yung Hyun Choi Selected Research

Alkaloids

1/2021Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells.
5/2019Camptothecin induces c-Myc- and Sp1-mediated hTERT expression in LNCaP cells: Involvement of reactive oxygen species and PI3K/Akt.
1/2016Sanguinarine Induces Apoptosis of Human Oral Squamous Cell Carcinoma KB Cells via Inactivation of the PI3K/Akt Signaling Pathway.
3/2015Synthesized tetrahydroisoquinoline alkaloid exerts anticancer effects at least in part by suppressing NF-κB-regulated proteins in A549 human lung cancer cells.
11/2014Camptothecin sensitizes human hepatoma Hep3B cells to TRAIL-mediated apoptosis via ROS-dependent death receptor 5 upregulation with the involvement of MAPKs.
7/2013Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction.
1/2013Apoptosis induction of human bladder cancer cells by sanguinarine through reactive oxygen species-mediated up-regulation of early growth response gene-1.
5/2009Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells.
1/2008Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation.
1/2008Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway.

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Yung Hyun Choi Research Topics

Disease

233Neoplasms (Cancer)
06/2022 - 12/2002
56Leukemia
01/2021 - 05/2005
52Carcinoma (Carcinomatosis)
03/2021 - 05/2002
44Urinary Bladder Neoplasms (Bladder Cancer)
06/2022 - 05/2006
37Inflammation (Inflammations)
09/2021 - 01/2006
35Mitochondrial Diseases (Mitochondrial Disease)
09/2022 - 11/2007
31Hepatocellular Carcinoma (Hepatoma)
10/2021 - 01/2006
24Breast Neoplasms (Breast Cancer)
01/2021 - 02/2004
22Neoplasm Metastasis (Metastasis)
03/2020 - 09/2005
18Prostatic Neoplasms (Prostate Cancer)
03/2022 - 01/2003
15Melanoma (Melanoma, Malignant)
07/2021 - 12/2004
15Lung Neoplasms (Lung Cancer)
08/2020 - 05/2002
14Colonic Neoplasms (Colon Cancer)
12/2019 - 11/2003
12Non-Muscle Invasive Bladder Neoplasms
07/2021 - 01/2010
9Infections
07/2022 - 11/2013
9Colorectal Neoplasms (Colorectal Cancer)
05/2022 - 01/2002
9Neurodegenerative Diseases (Neurodegenerative Disease)
11/2016 - 06/2007
7Stomach Neoplasms (Stomach Cancer)
03/2021 - 02/2011
7Necrosis
01/2021 - 05/2006
7Hypoxia (Hypoxemia)
04/2019 - 11/2009
7Renal Cell Carcinoma (Grawitz Tumor)
11/2018 - 06/2010
7Adenocarcinoma
03/2014 - 11/2007
6Bone Resorption
02/2022 - 12/2017
6Asthma (Bronchial Asthma)
12/2019 - 03/2008
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2019 - 08/2005
5Skin Diseases (Skin Disease)
09/2022 - 09/2013
5Rheumatoid Arthritis
05/2021 - 09/2007
5Weight Loss (Weight Reduction)
07/2020 - 11/2019
5Squamous Cell Carcinoma of Head and Neck
01/2017 - 01/2015
4Hyperplasia
03/2022 - 09/2007
4Hemorrhage
01/2022 - 05/2006

Drug/Important Bio-Agent (IBA)

50Proteins (Proteins, Gene)FDA Link
11/2021 - 11/2007
38Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2020 - 12/2006
37Reactive Oxygen Species (Oxygen Radicals)IBA
06/2022 - 05/2002
36CaspasesIBA
05/2022 - 12/2003
22NF-kappa B (NF-kB)IBA
06/2020 - 10/2003
21CytokinesIBA
05/2021 - 12/2006
21LigandsIBA
06/2019 - 05/2007
20Matrix Metalloproteinases (MMPs)IBA
06/2022 - 11/2008
19Ethanol (Ethyl Alcohol)IBA
06/2022 - 05/2006
19Caspase 3 (Caspase-3)IBA
01/2020 - 11/2003
17Pharmaceutical PreparationsIBA
06/2022 - 05/2006
17Telomerase (Telomerase Reverse Transcriptase)IBA
03/2015 - 04/2005
16DNA (Deoxyribonucleic Acid)IBA
11/2020 - 10/2004
14Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2019 - 04/2006
13AntioxidantsIBA
04/2021 - 05/2006
13Anthocyanins (Anthocyanin)IBA
03/2021 - 04/2009
12Cytochromes c (Cytochrome c)IBA
01/2022 - 02/2006
12Messenger RNA (mRNA)IBA
07/2021 - 04/2006
11LipopolysaccharidesIBA
05/2021 - 01/2008
11FlavonoidsIBA
01/2021 - 12/2008
11Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2020 - 04/2004
11ResveratrolIBA
05/2019 - 01/2003
11beta-lapachoneIBA
02/2016 - 03/2003
10AlkaloidsIBA
01/2021 - 01/2008
9Biomarkers (Surrogate Marker)IBA
03/2022 - 07/2016
9Biological ProductsIBA
10/2021 - 08/2004
9sulforaphaneIBA
09/2020 - 05/2007
9cordycepinIBA
01/2019 - 12/2010
8Matrix Metalloproteinase 9 (Gelatinase B)IBA
02/2018 - 10/2010
8sanguinarineIBA
01/2016 - 09/2007
7MicroRNAs (MicroRNA)IBA
07/2022 - 10/2016
7Bile Acids and Salts (Bile Acids)IBA
06/2022 - 09/2003
7Transcription Factors (Transcription Factor)IBA
10/2021 - 11/2009
7TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
01/2021 - 02/2008
7Antineoplastic Agents (Antineoplastics)IBA
11/2020 - 04/2012
7PolyphenolsIBA
01/2020 - 05/2006
7esculetinIBA
05/2016 - 03/2008
6Cisplatin (Platino)FDA LinkGeneric
01/2022 - 01/2015
6Peptides (Polypeptides)IBA
11/2020 - 01/2008
6Caspase 9IBA
01/2020 - 03/2009
6Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
07/2019 - 02/2009
6CurcuminIBA
05/2019 - 05/2006
6morinIBA
05/2019 - 10/2014
6Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2019 - 01/2003
6baicaleinIBA
01/2019 - 01/2006
6p38 Mitogen-Activated Protein KinasesIBA
01/2015 - 07/2009
6quinone (benzoquinone)IBA
01/2015 - 11/2003
5bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA
11/2021 - 02/2008
5Particulate MatterIBA
08/2021 - 07/2020
5Melanins (Melanin)IBA
07/2021 - 10/2010
5Auranofin (Ridaura)FDA Link
05/2021 - 04/2017
5Therapeutic UsesIBA
12/2019 - 04/2006
5GenisteinIBA
08/2019 - 11/2007
5Bee Venoms (Bee Venom)IBA
01/2019 - 12/2006
5Dinoprostone (PGE2)FDA Link
10/2018 - 06/2007
5buteinIBA
02/2018 - 12/2009
5isothiocyanic acidIBA
01/2018 - 07/2007
5Histone Deacetylase InhibitorsIBA
01/2015 - 08/2005
5HS 1200IBA
10/2008 - 09/2003
5Chenodeoxycholic Acid (Chenix)FDA Link
10/2008 - 09/2003
5OvalbuminIBA
10/2008 - 01/2008
4fisetinIBA
01/2022 - 01/2020
4Oxygen (Dioxygen)IBA
11/2021 - 03/2013
4JNK Mitogen-Activated Protein KinasesIBA
10/2021 - 11/2005
4CateninsIBA
10/2021 - 01/2020

Therapy/Procedure

22Therapeutics
02/2021 - 09/2003
14Traditional Medicine (Folk Remedies)
03/2020 - 06/2008
6Oral Administration
08/2021 - 04/2012
6Drug Therapy (Chemotherapy)
06/2008 - 04/2006